Excretion and Elimination
In the organism, enrofloxacin is partly transferred to metabolites, primarily to ciprofloxacin, which has similar antimicrobial activity (11).
Enrofloxacin and its active metabolite are excreted in bile (70%) and urine (30%) in concentrations far exceeding the plasma levels (12). Elimination through the kidneys occurs by glomerular filtration of the non protein-bound drug fraction and by active secretion via the organic anion transport system of the tubuli (1). Together with the excellent tissue penetration abilities of Baytril, high therapeutic concentrations not only in urine but also in the tissues of the genitourinary tract are achieved (13).
References
| (1) |
Brown SA: Fluoroquinolones in animal health. J vet Pharmacol Therap 19: 1-14, 1996. |
| (11) |
Greene CE, Budsberg SG: Veterinary use of quinolones, in Hooper DC, Wolfson JS (eds): Quinolone Antimicrobial Agents, ed 2. Washington DC, American Society for Microbiology: 473-488, 1993. |
| (12) |
Petzinger E: Gyrasehemmstoffe, eine neue Klasse von Chemotherapeutika. Tierärztl Prax 19: 14-20, 1991. |
| (13) |
Monlouis JD, DeJong A, Limet A, Richez P: Plasma pharmacokinetics and urine concentrations after oral administration of enrofloxacin to dogs. Proceedings 7th EAVPT Congress, Madrid: J vet Pharmacol Therap 20 (Suppl 1): 61-63, 1997. | |
