Skin Tissue Kinetics
Baytril quickly penetrates affected tissues and attains a high concentration in the skin which exceeds the corresponding plasma levels. Moreover, tissue levels are maintained for a longer time than in plasma.
In a recent study (5) enrofloxacin skin concentrations in dogs with pyoderma were compared to skin concentrations in healthy dogs. It was demonstrated that after 3 days of treatment with an oral dose of 5 mg/kg b.w. enrofloxacin once daily, mean dermal concentrations in pyoderma dogs were nearly 2 times higher than healthy dogs.
When cases of superficial pyoderma in this study were compared to cases of deep pyoderma, the mean skin levels of enrofloxacin in the more severe cases were around 2.5 times higher.
Those high concentrations of active drug at the site of infection ensure Baytrils excellent therapeutic activity against the majority of bacterial pathogens involved in skin infections.
References
| (5) |
DeManuelle TC, Ihrke PJ, Vulliet PR: Comparison of enrofloxacin skin concentrations in normal dogs and in dogs with pyoderma. Suppl Compend Contin Educ Pract Vet 21(12): 49-56, 1999. |
| (25) |
Stegemann M, Heukamp U, Scheer M, Krebber R: Kinetics of antibacterial activity after administration of enrofloxacin in dog serum and skin: in vitro susceptibility of field isolates. Suppl Compend Contin Educ Pract Vet 18 (2): 30-34, 1996. | |
