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Diseases / Urinary Tract Infections / Bacterial invasion strategies    

Bacterial invasion strategies

Pathogenic bacteria have developed different strategies to circumvent host defense mechanisms.

A number of pathogens attach to the uroepithelium by fimbriae to avoid washout during micturition. Some produce endotoxins decreasing urethral peristalsis in order to faciliate adhesion to the mucosa (O-antigens). Others produce substances like K-antigens, which interfere with opsonisation and phagocytosis, or they suppress the resident flora with bacteriocins, hemolysins and Fe-chelators (18).

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References
(18) Grauer GF: Urinary Tract Infections, in Allen DG (ed): Small Animal Medicine, Lippincott, Philadelphia: 625-655, 1991.

   
Bacteria in the urinary tract
Bacteria in the urinary tract