Drug Concentrations
Baytril concentrates in the urine via renal excretion, as well as active tubular secretion, greatly exceeding the corresponding plasma levels.
Active drug reaches the tissues of the urinary tract from the lumen via the urine, as well as from the systemic circulation.
Due to its amphoteric character and lipophilic properties, it readily crosses the blood-prostatic fluid barrier and attains high therapeutic concentrations within the prostatic tissue (20).
In this way, bacterial prostatitis, which otherwise may cause chronic recurrent infection of the urinary tract, can be competed effectively.
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References
| (20) | Dorfman M, Barsanti JA, Budsberg SC: Enrofloxacin concentrations in dogs with normal prostate and dogs with chronic bacterial prostatitis. Am J Vet Res (3): 386-390, 1995. |
| (24) | Monlouis JD, DeJong A, Limet A, Richez P: Plasma pharmacokinetics and urine concentrations after oral administration of enrofloxacin to dogs. Proceedings 7th EAVPT Congress, Madrid: J vet Pharmacol Therap 20 (Suppl 1): 61-63, 1997. |
