Infection and inflammation |
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| (1) |
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Bacteria invade tissues and liberate toxins and other substances. |
| (2) |
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Granulocytes are attracted to the affected area and migrate from the dilated vascular bed in great numbers. |
| (3) |
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Mast cells degranulate and liberate vasoactive amines. |
| (4) |
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The action of prostaglandins and leukotrienes causes leakage of plasma and protein. |
| (6) |
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Neutrophils and macrophages phagocytize bacteria, but also excrete numerous proteolytic enzymes, chemotactic and chemokinetic substances that attract more white cells. |
| (6) |
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Vasodilation is increased and the cardinal signs of inflammation appear. |
| (7) |
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The intercellular matrix is damaged; fibroblasts start forming collagen and proteo glycans. | |