| (1) |
Dogs' skin is much more delicate compared to other mammalian species. The delicate compact structure of the stratum corneum, it`s paucicity of intercellular lipid rich material, the relative high pH, and the absence of a lipid-squamous epithelium plug in the ostium of the hair follicle predispose this species to pyoderma. |
| (2) |
Normal follicle and sebaceous glands. Permanent secretion of sebum towards the skin surface clears hair follicles of bacteria. |
| (3) |
Flea bite leads to allergic inflammatory reaction causing pruritus. Scratching at the site of inflammation aggravates the condition and inoculates bacteria into the lesions. |
| (4) |
Demodex mites in the hair follicles and sebaceous glands cause hypersecretion of sebum and damage the follicle so that bacteria can cause secondary infection. |
| (5) |
Folliculitis. Bacterial infection has caused inflammation of the follicle with accumulation of pus and cellular debris. Massive accumulation of neutrophils and macrophages within the follicle. |
| (6) |
Deep follicular inflammation has led to follicular rupture and furunculosis. The infectious inflammatory process spreads to the perifollicular compartment. Free keratin from root sheath and hair shaft causes foreign body reaction and formation of sequestered foreign body granulomas. (2) |
| (7) |
Phagocytes, such as neutrophils and macrophages, incorporate large number of bacteria and foreign material. Staphylococci may survive phagocytosis and later cause recurrence of the condition. |
